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Shared Resources

Providing Expert Support for Specialized Research

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Our Shared Resources provides state-of-the-art services and technologies that deliver empowering and cost-effective support to our clinical, population and basic science investigators. Get the latest news about our resources.

Access Shared Resources’ Specialized Services. Contact information is included in each of the areas of expertise.

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Cancer Data Science [CDS]
CDS provides assistance to Rogel Cancer Center investigators in all quantitative aspects of cancer research. Visit webpage.

Director: Veera Baladandayuthapani, Ph.D.
Assistant: Lauren Detzler
Location: Washington Heights, M2030-26 SPH II
Phone: 734-936-0458

Cell and Tissue Imaging [CTI] (aka: BRCF Microscopy)
CTI is a centralized operation including more than 3,000 square feet focusing mainly on studies of cell and tissue morphology and ultrastructure. Visit webpage.

Managing Director: Jennifer Peters, Ph.D.
Facility Director: Nils Walter, Ph.D.
Locations: BSRB A830 | Med Sci II Rm 5631 | NCRC B20-53S
Phone: 734-936-4912

Epigenetics and Epigenomics [EE] (developing)
EE provides expertise & services for analysis of gene regulation for genome-wide (epigenomics) & locus-specific (epigenetics) studies in tumors and cancer tissues for DNA & histone modifications and chromatin accessibility/conformation. Visit the webpage.

Faculty Director: Dana Dolinoy, Ph.D.
Managing Director: Claudia Lalancette, Ph.D.
Phone: 734-764-2223
Location: MSRB 2, Room C568

Experimental Irradiation [EI]
EI provides extensive irradiation services to support research studies. Visit webpage.

Director: Meredith Morgan, Ph.D.
Manager: David Karnak, Ph.D.
Locations: 4310 Med Sci I, 3504E ARF Med Sci I, D714 BSRB, B026-G11N NCRC

Flow Cytometry [FLOW]
The FLOW provides support for clinical and basic science research investigators at Rogel, well as surrounding biotech institutions using state-of-the-art flow cytometry analysis and cell sorting. View the webpage.

Director: Thomas Moore, Ph.D.
Manager: David Adams, MsEd
Locations: C574 MSRB II | BSRB A701 | NCRC Bldg 20, 134D
Phone: 734-647-3216

Health Communications [HC]
HC provides communications services for research studies requiring targeted and tailored interventions that inform health decisions. View the web page

Director: Lawrence An, M.D.
Manager: Elizabeth Hershey
Location: NCRC, Bldg 16, Ground Floor
Phone: 734-763-6099

Immune Monitoring [IM]
IM provides immunologic and biological support for ongoing research projects and clinical trials at Rogel Cancer Center and the biomedical community at the University of Michigan. View the webpage.

Co-Directors: Fei Wen, Ph.D.
Maria Castro, Ph.D.

Manager, Immune Monitoring: Joel Whitfield
Manager, CyTOF: Luke Bugada

Locations: MSB 2 4725; NCRC B028-G019E

Liquid Biopsy [LB] (developing)
LB provides state-of-the-art engineering solutions and platforms to analyze liquid biopsies, including cell-free nucleic acid, circulating tumor cells, immune cells, and extracellular vesicles. View the webpage

Directors: Sunitha Nagrath, Ph.D.
Aaron Udager, M.D., Ph.D.
Simpa Salami, M.D.

Pharmacokinetics [PK]
PK facilitates both preclinical and clinical pharmacokinetic-based cancer research efforts through a range of services. View the webpage.

Director: Duxin Sun, Ph.D.
Managers: Bo Wen
Amit Pai, PharmD.
Location: NCRC, Bldg 520, 3400M
Phone: 734-615-8740

Preclinical Molecular Imaging [PMI]
PMI uses the latest imaging instruments, in a state-of-the-art facility, for expert computational analysis. Visit the webpage.

Director: Brian Ross, Ph.D.
Manager: Amanda Fair
Phone: 734-615-3009

Proteomics Resource Facility [PRF]
Mass spectrometry-based PRF assists researchers in designing proteomic experiment, maintain state-of-the-art instrumentation, provide technical expertise and bioinformatic support during both discovery and validation phases of proteomic experiments. View the webpage.

Director: Alexey Nesvizhskii, Ph.D.
Manager: Venkatesha Basrur, Ph.D.
Location: Rm 3554/3556, MSRB
Phone: 734-615-5722

Single Cell Spatial Analysis [SCSA]
SCA provides expertise to basic and clinical sciences research investigators at Rogel Cancer Center and surrounding institutions. View the webpage.

Co-Directors: Evan T. Keller, D.V.M., Ph.D.
Thomas Wilson, M.D., Ph.D.
Managing Director: Olivia Koues, Ph.D.
Associate Manager Greg Shelley, Ph.D.
Location: NCRC, Bldg 20, 334W-D
Email: [email protected]

Structure and Drug Screening [SDS]
SDS supports and enhances cancer research projects through collaborative efforts. View the webpage.

Co-directors: Andrew Alt, Ph.D., Center for Chemical Genomics
Janet Smith, Ph.D., Center for Structural Biology
Managers: Jeanne Stuckey, Ph.D., Center for Structural Biology
Andrew White, Ph.D., Medicinal Chemistry, College of Pharmacy
Locations: Life Sciences Institute, 210 Washtenaw, Room 3358; College of Pharmacy, 4562 CC Little, 428 Church St.
Phone: 734-647-8098

Tissue and Molecular Pathology [TMP]
TMP consists of three distinct, yet complementary services relating to the procurement and evaluation of tissue for research: Tissue Procurement, Histology, and Molecular Pathology. View the webpage.

Co-Directors: Thomas Giordano, M.D., Ph.D.
Steven Hrycaj, Ph.D.
Managing Director: Dafydd Thomas, M.D., Ph.D.
General questions: Thomas Giordano, Ph.D.
Phone: 734-647-3261

Transgenic Animal Models [TAM]
TAM provides complex technology solutions. Working in collaboration with the Bacterial Artificial Chromosome Recombineering Core, we provide effective tools for successful research. View the webpage.

Director: Zachary Freeman, D.V.M, Ph.D. [Interim]
Manager: Elizabeth Hughes, M.S.
Location: 2570 MSRB II
Phone: 734-647-2910

Important Resources

Logo for the Instrumental resource newsletter for shared resources

 

DR. KELLER'S MESSAGE | SERVICE SPOTLIGHT | RESEARCH SPOTLIGHT | NEWS AND UPDATES  | CONTACT OUR TEAM

A message from Dr. Keller

With the new year in our sights, it is easy to begin looking ahead to the things we will set out to do in 2024. While forward thinking is crucial in our efforts as researchers, it is also beneficial to reflect on the things we accomplished in 2023.

After successfully competing for our Cancer Center Support Grant renewal, we added four new Shared Resources to our growing list: Liquid Biopsy and Epigenetics & Epigenomics (developing); and Single Cell Spatial Analysis and Proteomics (full shared resources). This brings our current total to 13.

Together, our shared resources have served hundreds of investigators. They have tested and adopted new technologies, conducted workshops and seminars, and have contributed to numerous grant submissions and publications. I am thankful for the dedication and expertise of our faculty and staff and for the opportunity to support the innovative research projects of our Rogel members.

As we move into the holiday season many of our shared resources have modified hours of operation. Please reach out directly if you have questions about staff or instrument availability during this time. We wish you all a safe and happy holiday season and we look forward to collaborating with you in the coming year.

 

Service Spotlight

Preclinical Molecular Imaging Shared Resource (PMI-SR)

The Preclinical Molecular Imaging Shared Resource (PMI-SR) supports multimodal imaging-centric research and state-of-the-art imaging capabilities and scientific expertise.

Technologies available include Magnetic Resonance Imaging (MRI); Bioluminescence Imaging (BLI); Fluorescence Imaging (FLI); Computed Tomography (CT); and Positron Emission Tomography (PET).

The newest technology added to the PMI-SR is the result of a successful NIH S10 application. The NHD Preclinical Scanner is a 4DMedical multimodal scanner capable of acquiring lung with high-resolution, high-contrast structural detail and functional ventilation-perfusion mismatch without the need for contrast agents. Investigators conducting studies in rodent models specific to lung tumors or the effects of lung irradiation serve to benefit from employing this safe, quick, and inexpensive tool that provides high-resolution images in addition to detailed regional information on lung function.

To schedule a consultation, request training, or to schedule instrument time please contact PMI-SR Director Brian D. Ross, Ph.D. ([email protected]), or facility manager Amanda Fair ([email protected]).

 

Research Spotlight

Xu Lab

A recent manuscript by Choi et al. from lab of Zhen Xu, Ph.D. (DT) conducted a preclinical investigation into the use of histotripsy, a non-surgical approach to ablating tissue in vivo.

Histotripsy is the process of applying microsecond-length high-pressure ultrasound pulses resulting in cavitation. In the present study, various histotripsy dosages were administered to murine models of primary and metastatic brain cancer and lung metastasis.

Investigators used the 7T MRI and bioluminescence imaging systems available within the Preclinical Molecular Imaging Shared Resource to monitor post-transplantation tumor growth and for the evaluation of post-treatment tumor damage, associated bleeding, and edema. Results suggest that a lower number of histotripsy pulses and fewer focal locations can kill a substantial number of tumor cells while minimizing bleeding and cellular injury.

Authors also credit the Tissue & Molecular Pathology Shared Resource for tissue embedding and H&E staining.

Read the full manuscript: Transcranial histotripsy parameter study in primary and metastatic murine brain tumor models.

 

News and Updates

Cancer Data Science adds assistant director

The Rogel Cancer Center is pleased to announce the recent appointment of Gen Li, Ph.D. as assistant director of the Cancer Data Science Shared Resource (CDS-SR). Dr. Li, associate professor in the Department of Biostatistics, will will provide scientific leadership for the enhancement of genomic data analyses and integration and will build and promote initiatives in the area of laboratory sciences. He will work in partnership with CDS-SR Director Veera Baladandayuthapani, Ph.D.

New instruments and updated workflows at the Advanced Genomics Core

Recent updates to the BRCF Advanced Genomics Core (AGC) will provide new options for users of our Single Cell Spatial Analysis and Epigenetics and Epigenomics Shared Resources. The AGC recently added a NovaSeq X Plus, the latest sequencer from Illumina, that provides extraordinary sequencing power to fuel data-intensive applications like whole-genome sequencing, single-cell sequencing, and multiomics. A second Oxford Nanopore Technologies (ONT) instrument, the PromethION24 that accommodates up to 24 independently addressable, high-capacity flow cells, has also been added. To allow for streamlined single cell sequencing, the 10X Genomics Single Cell Gene Expression Flex workflow has been adopted. This workflow is compatible with fresh, frozen, PFA fixed, or FFPE tissues for both mouse and human samples. The assay has built in multiplexing capability, is compatible with TotalSeq C labeling for cell surface protein expression, and flow sorting enrichment for cells of interest. For a complete list of technologies supported by the Advanced Genomics Core please visit their website.

Immune Monitoring offering expanded CYTOF panel and new Rogel member subsidy

The Immune Monitoring Shared Resource (IM-SR) is offering new and expanded antibody panels for 8-33 color FFPE tissue imaging and suspension analysis using CYTOF. In addition, Rogel members are now eligible to receive up to $1,200 off CYTOF services. Limited funds are available, please contact IM-SR Co-Director Fei Wen, Ph.D.([email protected]) to inquire.

Holiday hours

In observance of the seasonal holidays, many of our SRs have adjusted their staffing and hours of operation. If the SR you are seeking is not included in the list below, please visit their website for the most up-to-date information.

  • Cell and Tissue will have no staff available between December 25 and January 1. Trained users who already have access can continue to use the facilities on their own at any time. Please contact Director Jennifer Peters, Ph.D. ([email protected]) for more information.
  • Epigentics and Epigenomics will close for the holidays at 4:30 p.m. December 21 and reopen January 2. Please contact Managing Director Claudia Lalancette, Ph.D. ([email protected]) for more information.
  • Flow Cytometry will be unavailable for staffed operations December 25 through January 1. Please use the MiCORES website to schedule self-assist operations during this time.
  • Preclinical Molectular Imaging will be closed December 22 and will reopen on January 2. The IVIS Spectrum and NCRC IVIS Lumina will remain available for holiday scheduling for those who have been previously trained and have access.
  • Proteomics will be closed from December 25 through January 1. Regular operations will resume on January 2. Please contact Director Alexey Nesvizhskii, Ph.D. ([email protected]) for more information.
  • Transgenic Animal Models will close at 5 p.m. December 21 and re-open at 8 a.m. January 2. Please contact the Transgenic Core ([email protected]) for more information.

 

Keep up-to-date on Shared Resources: Read the Instrumental

Contact Shared Resources for More Information

If you have questions about Shared Resources services at the University of Michigan Rogel Cancer Center, please contact us for more information. Fill out our feedback form and help us improve our services!

Associate Director: Evan Keller, DVM, Ph.D.

Research Administrator: Kimberly Zuhlke

Location: 6216 Rogel Cancer Center
Phone: 734-647-7222

 

Shared Resources Training Seminar Series is on hiatus

This series is designed for all Rogel members, with a specific emphasis on trainees and postdocs within member labs.

Presentations will focus on development of methodologies, new techniques, data interpretation, sample procurement, quality control, etc. Speakers may consist of expert staff from within our SRs or field application specialists from industry partners. The series is a collaboration between the Rogel Cancer Center Shared Resource and Training, Education, and Career Development (TrEC) teams.

Watch past seminars on Dropbox!

SDS-SR: Make it one of your first stops on the road to developing a new cancer therapeutic
Rogel Structure and Drug Screening Shared Resource, Jeanne Stuckey, Ph.D. presented on June 9, 2022

Positron emission tomography: molecular imaging in the age of personalized medicine
Preclinical Molecular Imaging Shared Resource, Peter J.H. Scott, Ph.D. presented on April 7, 2022

Multiplex immunofluorescence and whole slide imaging: understanding complex phenotypes and microenvironments through multispectral analysis
Tissue and Molecular Pathology, Paul Harms, M.D., Ph.D., co-director
Presented by Timothy Frankel, M.D. on March 3, 2022.

The ins and outs of PK-PD.
Pharmacokinetics
Presented by Amit Pai, PharmD. on February 3, 2022

The BRCF Microscopy Core: Current Technologies and Future Plans
BRCF Microscopy
Presented by Jennifer Peters, Ph.D. on December 2

Design and analysis of quantitative proteomics experiments
Proteomics Resource Facility
Presented by Felipe da Veiga Leprevost, Ph.D. and Sarah Haynes, Ph.D. on November 4

Introduction to CyTOF: 40-parameter analysis of single cells and tissue sections
Immune Monitoring Shared Resource
Presented by Luke Bugada on October 7, 2021