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Shared Resources

Providing Expert Support for Specialized Research

image of spiraled single cell construct

Our Shared Resources provides state-of-the-art services and technologies that deliver empowering and cost-effective support to our clinical, population and basic science investigators. Get the latest news about our resources.

Access Shared Resources’ Specialized Services. Contact information is included in each of the areas of expertise.

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Cancer Data Science [CDS]
CDS provides assistance to Rogel Cancer Center investigators in all quantitative aspects of cancer research. Visit webpage.

Director: Veera Baladandayuthapani, Ph.D.
Assistant: Lauren Detzler
Location: Washington Heights, M2030-26 SPH II
Phone: 734-936-0458

Cell and Tissue Imaging [CTI] (aka: BRCF Microscopy)
CTI is a centralized operation including more than 3,000 square feet focusing mainly on studies of cell and tissue morphology and ultrastructure. Visit webpage.

Managing Director: Jennifer Peters, Ph.D.
Facility Director: Nils Walter, Ph.D.
Locations: BSRB A830 | Med Sci II Rm 5631 | NCRC B20-53S
Phone: 734-936-4912

Epigenetics and Epigenomics [EE] (developing)
EE provides expertise & services for analysis of gene regulation for genome-wide (epigenomics) & locus-specific (epigenetics) studies in tumors and cancer tissues for DNA & histone modifications and chromatin accessibility/conformation. Visit the webpage.

Faculty Director: Dana Dolinoy, Ph.D.
Managing Director: Claudia Lalancette, Ph.D.
Phone: 734-764-2223
Location: MSRB 2, Room C568

Experimental Irradiation [EI]
EI provides extensive irradiation services to support research studies. Visit webpage.

Director: Meredith Morgan, Ph.D.
Manager: David Karnak, Ph.D.
Locations: 4310 Med Sci I, 3504E ARF Med Sci I, D714 BSRB, B026-G11N NCRC

Flow Cytometry [FLOW]
The FLOW provides support for clinical and basic science research investigators at Rogel, well as surrounding biotech institutions using state-of-the-art flow cytometry analysis and cell sorting. View the webpage.

Director: Thomas Moore, Ph.D.
Manager: David Adams, MsEd
Locations: C574 MSRB II | BSRB A701 | NCRC Bldg 20, 134D
Phone: 734-647-3216

Health Communications [HC]
HC provides communications services for research studies requiring targeted and tailored interventions that inform health decisions. View the web page

Director: Lawrence An, M.D.
Manager: Elizabeth Hershey
Location: NCRC, Bldg 16, Ground Floor
Phone: 734-763-6099

Immune Monitoring [IM]
IM provides immunologic and biological support for ongoing research projects and clinical trials at Rogel Cancer Center and the biomedical community at the University of Michigan. View the webpage.

Co-Directors: Fei Wen, Ph.D.
Maria Castro, Ph.D.

Manager, Immune Monitoring: Joel Whitfield
Manager, CyTOF: Luke Bugada

Locations: MSB 2 4725; NCRC B028-G019E

Liquid Biopsy [LB] (developing)
LB provides state-of-the-art engineering solutions and platforms to analyze liquid biopsies, including cell-free nucleic acid, circulating tumor cells, immune cells, and extracellular vesicles. View the webpage

Directors: Sunitha Nagrath, Ph.D.
Aaron Udager, M.D., Ph.D.
Simpa Salami, M.D.

Pharmacokinetics [PK]
PK facilitates both preclinical and clinical pharmacokinetic-based cancer research efforts through a range of services. View the webpage.

Director: Duxin Sun, Ph.D.
Managers: Bo Wen
Amit Pai, PharmD.
Location: NCRC, Bldg 520, 3400M
Phone: 734-615-8740

Preclinical Molecular Imaging [PMI]
PMI uses the latest imaging instruments, in a state-of-the-art facility, for expert computational analysis. Visit the webpage.

Director: Brian Ross, Ph.D.
Manager: Amanda Fair
Phone: 734-615-3009

Proteomics Resource Facility [PRF]
Mass spectrometry-based PRF assists researchers in designing proteomic experiment, maintain state-of-the-art instrumentation, provide technical expertise and bioinformatic support during both discovery and validation phases of proteomic experiments. View the webpage.

Director: Alexey Nesvizhskii, Ph.D.
Manager: Venkatesha Basrur, Ph.D.
Location: Rm 3554/3556, MSRB
Phone: 734-615-5722

Single Cell Spatial Analysis [SCSA]
SCA provides expertise to basic and clinical sciences research investigators at Rogel Cancer Center and surrounding institutions. View the webpage.

Co-Directors: Evan T. Keller, D.V.M., Ph.D.
Thomas Wilson, M.D., Ph.D.
Managing Director: Olivia Koues, Ph.D.
Associate Manager Greg Shelley, Ph.D.
Location: NCRC, Bldg 20, 334W-D
Email: [email protected]

Structure and Drug Screening [SDS]
SDS supports and enhances cancer research projects through collaborative efforts. View the webpage.

Co-directors: Andrew Alt, Ph.D., Center for Chemical Genomics
Janet Smith, Ph.D., Center for Structural Biology
Managers: Jeanne Stuckey, Ph.D., Center for Structural Biology
Andrew White, Ph.D., Medicinal Chemistry, College of Pharmacy
Locations: Life Sciences Institute, 210 Washtenaw, Room 3358; College of Pharmacy, 4562 CC Little, 428 Church St.
Phone: 734-647-8098

Tissue and Molecular Pathology [TMP]
TMP consists of three distinct, yet complementary services relating to the procurement and evaluation of tissue for research: Tissue Procurement, Histology, and Molecular Pathology. View the webpage.

Co-Directors: Thomas Giordano, M.D., Ph.D.
Steven Hrycaj, Ph.D.
Managing Director: Dafydd Thomas, M.D., Ph.D.
General questions: Thomas Giordano, Ph.D.
Phone: 734-647-3261

Transgenic Animal Models [TAM]
TAM provides complex technology solutions. Working in collaboration with the Bacterial Artificial Chromosome Recombineering Core, we provide effective tools for successful research. View the webpage.

Director: Zachary Freeman, D.V.M, Ph.D. [Interim]
Manager: Elizabeth Hughes, M.S.
Location: 2570 MSRB II
Phone: 734-647-2910

Important Resources

Logo for the Instrumental resource newsletter for shared resources

 

SERVICE SPOTLIGHT | NEWS AND UPDATES | RESEARCH SPOTLIGHT | MEET THE EXPERTS | CONTACT OUR TEAM

 

Service Spotlight

Transgenic Animal Models Shared Resource (TAM-SR)

The Transgenic Animal Models Shared Resource (TAM-SR), located on the C-Floor of Medical Sciences Research Building II (MRSB-II), provides specialized equipment and expertise in transgenic technology and genome engineering to Rogel members. Having produced over 20,000 transgenic mice and rats since its establishment in 1989, the SR has validated methods that allow for guaranteed production of at least three transgenic founder mice or rats per transgene DNA construct.

TAM-SR also offers training in the principles of genome engineering, CRISPR/Cas9 technology, mouse embryonic stem (ES) cell technology, and technical bench-level microinjection. Training is coupled with access to lab space and equipment, allowing users to work side-by-side with TAM-SR staff to produce genetically modified mice, rats, and mouse ES cell lines that can be used to increase our understanding of gene function in cancer.

accessibility/conformation.

 

News and Updates

Rogel Seeks Assistant Director for Shared Resources

Rogel is seeking an Assistant Director for Shared Resources to provide leadership for Rogel initiatives that further enhance the utility, value, innovation, and impact of our shared resources. The Assistant Director for Shared Resources will work under the direction of the Associate Director for Shared Resources. The role is expected to require 5% effort commitment.

For additional information and to apply visit: https://umms.infoready4.com/#competitionDetail/1942417.

Cancer Data Science Welcomes Program Manager

The Cancer Data Science Shared Resource (CDS-SR) is happy to welcome Program Manager Erik Roys to the SR staff. Erik has a master’s degree in clinical research design and statistical analysis from the University of Michigan School of Public Health. He has been involved in statistical analysis and reporting related to the evaluation of healthcare providers throughout his career.

Rogel members requiring biostatistical or bioinformatics support can email [email protected] to schedule consultations or submit a request for assistance on-line at https://sph.umich.edu/cds/assistance.html.

Hughes Retires

Interim Managing Director of the Transgenic Animal Models Shared Resource, Elizabeth Hughes, celebrated her retirement on April 26, 2024. We wish Elizabeth a happy retirement and thank her for her more than 20 years of dedicated service.

Rogel SR Survey Raffle Winners

Thank you to everyone that took the time to reply to our recent Rogel Shared Resource Survey. Your thoughtful responses provide the information we need to make decisions on future investments and help us to understand the things we are doing well and the opportunities we have for improvement.

Four raffle winners were selected from the pool of 116 respondents. Congratulations to the following Rogel members who will receive a $30 Zingerman’s gift card:

  • Jiandie Lin (STME)
  • Antonio Morales-Hernandez (CHI)
  • Susan Pitt (CCPS)
  • Arvind Rao (TACR)

Cell and Tissue Imaging offers new technologies, NCRC Open House, and EM Summer Series

The Cell and Tissue Imaging Shared Resource (CTI-SR), a.k.a. BRCF Microscopy Core, recently upgraded its lab space at the North Campus Research Complex (NCRC) making it suitable for handling BSL2 samples. The location, which will be staffed approximately 20 hours per week, now includes:

CTI-SR will host an open house on Thursday, August 8 to showcase the renovation and expanded services. Please join us for the following:

OPEN HOUSE – SCHEDULED EVENTS

  • 1:30 – 2 p.m. - Building 20, Room 53S - brief welcome and ribbon cutting
  • 2 – 3 p.m. - Building 10, Rooms G063/G064 – Discussion of available Nikon technologies - presented by Nikon Instruments.
  • 3 – 5 p.m. - Facility tours and instrument demonstrations

Get more information by visiting the Microscopy Core NCRC Open House web page.

Interested in learning more about 3D electron microscopy (EM) and other advanced methods?

The CTI-SR is starting an Advanced Biological EM Methods Interest Group for U-M scientists with diverse research interests to have the opportunity to interact and learn from one another. This group will also help SR leadership to gauge interest on the development of new services. We will begin with a series of three introductory talks by Jing Liang, Ph.D., Senior Electron Microscopy Scientist. These talks will be presented in a hybrid format on July 10, 17, and 24, from 3:00 – 4:00 pm with the in-person portion at the Biomedical Science Research Building (BSRB), room 2515.

For additional information on CTI-SR events, training, consultations, or other happenings, please contact Managing Director, Jennifer Peters, Ph.D., [email protected].

 

Research Spotlight

Metabolic-associated fatty liver disease – the accumulation of fat in liver cells – can progress to metabolic dysfunction-associated steatohepatitis (MASH) [formerly called nonalcoholic steatohepatitis (NASH)] which is characterized by liver injury, inflammation, and fibrosis. Progression to MASH increases the risk of developing end-stage liver disease including cirrhosis and hepatocellular carcinoma.

In a recent publication, the laboratory of Jiandie Lin, Ph.D. investigated the mechanism for which induction of triggering receptor expressed on myeloid cells 2 (TREM2+) NASH-associated macrophages (NAMs) contributes to MASH pathogenesis. Researchers identified membrane-spanning 4-domains a7 (MS4A7) as a NAM-specific pathogenic factor and utilized the CRISPR/Cas9 services in the Transgenic Animal Models Shared Resource to create a knockout mouse allowing them to investigate the pathophysiological role of this factor in MASH. The work revealed MS4A7s role in activating the NLRP3 inflammasome and driving MASH progression.

Authors also credit the use of the following Rogel Shared Resources: Flow Cytometry for cell sorting and analysis, Immune Monitoring for ELISA assays, and Single Cell Spatial Analysis for single cell RNA-seq

Read the full manuscript: Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation

Also featured by the Life Sciences Institute

 

Meet the Expert: Cancer Data Science

Chamila Perera, Ph.D.
Statistician Senior, Biostatistics Department

What is your area of expertise?
Machine learning, high dimensional data analysis, precision medicine.

What types of analyses do you run most frequently?
Survival and longitudinal data analysis, predictive modeling, variable selection.

What do you like best about working in the SR?
Collaborating with talented researchers and clinicians from diverse backgrounds allows me to gain new insights and approaches to solving problems in cancer data analysis.

What is your favorite place in Ann Arbor?
Island Park, Briarwood Mall

Keep up-to-date on Shared Resources: Read the Instrumental

Contact Shared Resources for More Information

If you have questions about Shared Resources services at the University of Michigan Rogel Cancer Center, please contact us for more information. Fill out our feedback form and help us improve our services!

Associate Director: Evan Keller, DVM, Ph.D.

Research Administrator: Kimberly Zuhlke

Location: 6216 Rogel Cancer Center
Phone: 734-647-7222

 

Shared Resources Training Seminar Series is on hiatus

This series is designed for all Rogel members, with a specific emphasis on trainees and postdocs within member labs.

Presentations will focus on development of methodologies, new techniques, data interpretation, sample procurement, quality control, etc. Speakers may consist of expert staff from within our SRs or field application specialists from industry partners. The series is a collaboration between the Rogel Cancer Center Shared Resource and Training, Education, and Career Development (TrEC) teams.

Watch past seminars on Dropbox!

SDS-SR: Make it one of your first stops on the road to developing a new cancer therapeutic
Rogel Structure and Drug Screening Shared Resource, Jeanne Stuckey, Ph.D. presented on June 9, 2022

Positron emission tomography: molecular imaging in the age of personalized medicine
Preclinical Molecular Imaging Shared Resource, Peter J.H. Scott, Ph.D. presented on April 7, 2022

Multiplex immunofluorescence and whole slide imaging: understanding complex phenotypes and microenvironments through multispectral analysis
Tissue and Molecular Pathology, Paul Harms, M.D., Ph.D., co-director
Presented by Timothy Frankel, M.D. on March 3, 2022.

The ins and outs of PK-PD.
Pharmacokinetics
Presented by Amit Pai, PharmD. on February 3, 2022

The BRCF Microscopy Core: Current Technologies and Future Plans
BRCF Microscopy
Presented by Jennifer Peters, Ph.D. on December 2

Design and analysis of quantitative proteomics experiments
Proteomics Resource Facility
Presented by Felipe da Veiga Leprevost, Ph.D. and Sarah Haynes, Ph.D. on November 4

Introduction to CyTOF: 40-parameter analysis of single cells and tissue sections
Immune Monitoring Shared Resource
Presented by Luke Bugada on October 7, 2021