MENURecent Publications from Cancer Center Members
Dozens of research papers are published monthly by Rogel Cancer Center members. Here is a selection of recent high-impact publications:
Cancer Biology
Cho, C. S.; Park, H. W.; Ho, A.; Semple, I. A.; Kim, B.; Jang, I.; Park, H.; Reilly, S.; Saltiel, A. R.; Lee, J. H. Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation. Hepatology (2018) 68:1331-1346. PMID: 29251796. PMCID: PMC6005718.
Cancer Epidemiology and Prevention
Mondul, A. M.; Weinstein, S. J.; Parisi, D.; Um, C. Y.; McCollough, M. L.; Albanes, D. Vitamin D binding protein and risk of renal cell carcinoma in the Cancer Prevention Study-II Cohort. Cancer Epidemiol Biomarkers Prev (2018) 27:1203-1207. PMID: 30030213. PMCID: PMC6170717.
INTER-PROGRAMMATIC PUBLICATIONS
Cancer Biology & Translational and Clinical Research
El Kadi, N.; Wang, L.; Davis, A.; Korkaya, H.; Cooke, A.; Vadnala, V.; Brown, N. A.; Betz, B. L.; Cascalho, M.; Kalemkerian, G. P.; Hassan, K. A. The EGFR T790M mutation is acquired through AICDA-mediated deamination of 5-methylcytosine following TKI treatment in lung cancer. Cancer Res (2018) In process. PMID: 30333118.
Previous publications:
Cancer Biology
Feinberg, T. Y.; Zheng, H.; Liu, R.; Wicha, M. S.; Yu, S. M.; Weiss, S. J. Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs. Dev Cell (2018) In process. PMID: 30269950.
Cancer Epidemiology and Prevention
Chang, J. T.; Levy, D. T.; Meza, R. Examining the Transitions between Cigarette and Smokeless Tobacco Product Use in the United States Using the 2002-2003 and 2010-2011 Longitudinal Cohorts. Nicotine Tob Res (2018) 20:1412-1416. PMID: 29126271. PMCID: PMC6154991.
Developmental Therapeutics
Henderson, A. R.; Henley, M. J.; Foster, N. J.; Peiffer, A. L.; Beyersdorf, M. S.; Stanford, K. D.; Sturlis, S. M.; Linhares, B. M.; Hill, Z. B.; Wells, J. A.; Cierpicki, T.; Brooks, C. L. 3rd; Fierke, C. A.; Mapp, A. K. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proc Natl Acad Sci U S A (2018) 115:8960-8965. PMID: 30127017. PMCID: PMC6130367.
Inter-Programmatic Publications
Cancer Biology & Cancer Hematopoiesis and Immunology
Fujiwara, H.; Docampo, M. D.; Riwes, M.; Peltier, D.; Toubai, T.; Henig, I.; Wu, S. J.; Kim, S.; Taylor, A.; Brabbs, S.; Liu, C.; Zajac, C.; Oravecz-Wilson, K.; Sun, Y.; Nunez, G.; Levine, J. E.; van den Brink, M. R. M.; Ferrara, J. L. M.; Reddy, P. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat Commun (2018) 9:3674. PMID: 30201970. PMCID: PMC6131147.
Cancer Genetics & Translational and Clinical Research
Giraldez, M. D.; Spengler, R. M.; Etheridge, A.; Godoy, P. M.; Barczak, A. J.; Srinivasan, S.; De Hoff, P. L.; Tanriverdi, K.; Courtright, A.; Lu, S.; Khoory, J.; Rubio, R.; Baxter, D.; Driedonks, T. A. P.; Buermans, H. P. J.; Nolte-'t Hoen, E. N. M.; Jiang, H.; Wang, K.; Ghiran, I.; Wang, Y. E.; Van Keuren-Jensen, K.; Freedman, J. E.; Woodruff, P. G.; Laurent, L. C.; Erle, D. J.; Galas, D. J.; Tewari, M. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol (2018) 36:746-757. PMID: 30010675. PMCID: PMC6078798.
Cancer Gentics, Cancer Hematopoiesis and Immunology & Developmental Therapeutics
Wang, Q.; Yan, R.; Pinnell, N.; McCarter, A. C.; Oh, Y.; Liu, Y.; Sha, C.; Garber, N. F.; Chen, Y.; Wu, Q.; Ku, C. J.; Tran, I.; Serna Alarcon, A.; Kuick, R.; Engel, J. D.; Maillard, I.; Cierpicki, T.; Chiang, M. Y. Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Blood (2018) 132:1279-1292. PMID: 30076146. PMCID: PMC6148450.
Cancer Genetics
Ludlow, A. T.; Wong, M. S.; Robin, J. D.; Batten, K.; Yuan, L.; Lai, T. P.; Dahlson, N.; Zhang, L.; Mender, I.; Tedone, E.; Sayed, M. E.; Wright, W. E.; Shay, J. W. NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nat Commun (2018) 9:3112. PMID: 30082712. PMCID: PMC6079032.
Translational and Cancer Research
Paoletti, C.; Schiavon, G.; Dolce, E. M.; Darga, E. P.; Carr, T. H.; Geradts, J.; Hoch, M.; Klinowska, T.; Lindemann, J. P. O.; Marshall, G.; Morgan, S.; Patel, P.; Rowlands, V.; Sathiyayogan, N.; Aung, K.; Hamilton, E. P.; Patel, M. R.; Armstrong, A. C.; Jhaveri, K.; Im, S. A.; Iqbal, N.; Butt, F.; Dive, C.; Harrington, E. A.; Barrett, J. C.; Baird, R. D.; Hayes, D. F. Circulating biomarkers and resistance to endocrine therapy in metastatic breast cancers: correlative results from AZD9496 oral SERD Phase I trial. Clin Cancer Res (2018) In process. PMID: 30082476.
Sahai, V.; Catalano, P. J.; Zalupski, M. M.; Lubner, S. J.; Menge, M. R.; Nimeiri, H. S.; Munshi, H. G.; Benson, A. B. 3rd; O'Dwyer, P. J. Nab-Paclitaxel and Gemcitabine as First-line Treatment of Advanced or Metastatic Cholangiocarcinoma: A Phase 2 Clinical Trial. JAMA Oncol (2018) In process. PMID: 30178032.
INTER-PROGRAMMATIC PUBLICATIONS
Cancer Biology & Cancer Hematopoiesis and Immunology
Khoriaty, R.; Hesketh, G. G.; Bernard, A.; Weyand, A. C.; Mellacheruvu, D.; Zhu, G.; Hoenerhoff, M. J.; McGee, B.; Everett, L.; Adams, E. J.; Zhang, B.; Saunders, T. L.; Nesvizhskii, A. I.; Klionsky, D. J.; Shavit, J. A.; Gingras, A. C.; Ginsburg, D. Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A (2018) 115:E7748-E7757. PMID: 30065114. PMCID: PMC6099849.
Cancer Genetics & Translational and Cancer Research
Xiao, L.; Tien, J. C.; Vo, J.; Tan, M.; Parolia, A.; Zhang, Y.; Wang, L.; Qiao, Y.; Shukla, S.; Wang, X.; Zheng, H.; Su, F.; Jing, X.; Luo, E.; Delekta, A.; Juckette, K. M.; Xu, A.; Cao, X.; Alva, A. S.; Kim, Y.; Macleod, A. R.; Chinnaiyan, A. M. Epigenetic reprogramming with antisense oligonucleotides enhances the effectiveness of androgen receptor inhibition in castration-resistant prostate cancer. Cancer Res (2018) In process. PMID: 30135193.
Cancer Biology
Zhou, W.; Xu, J.; Tan, M.; Li, H.; Li, H.; Wei, W.; Sun, Y. UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. Mol Cell (2018) 70:1008-1024.e6. PMID: 29932898. PMCID: PMC6021141.
Cancer Epidemiology and Prevention
Brouwer, A. F.; Eisenberg, M. C.; Meza, R. Case Studies of Gastric, Lung, and Oral Cancer Connect Etiologic Agent Prevalence to Cancer Incidence. Cancer Res (2018) 78:3386-3396. PMID: 29907681. PMCID: PMC6007874.
Fritsche, L. G.; Gruber, S. B.; Wu, Z.; Schmidt, E. M.; Zawistowski, M.; Moser, S. E.; Blanc, V. M.; Brummett, C. M.; Kheterpal, S.; Abecasis, G. R.; Mukherjee, B. Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative. Am J Hum Genet (2018) 102:1048-1061. PMID: 29779563. PMCID: PMC5992124.
Cancer Genetics
Krajewski, W. A.; Li, J.; Dou, Y. Effects of histone H2B ubiquitylation on the nucleosome structure and dynamics. Nucleic Acids Res (2018) In process. PMID: 29931239.
Health Behavior and Outcomes
Kurian, A. W.; Bondarenko, I.; Jagsi, R.; Friese, C. R.; McLeod, M. C.; Hawley, S. T.; Hamilton, A. S.; Ward, K. C.; Hofer, T. P.; Katz, S. J. Recent Trends in Chemotherapy Use and Oncologists' Treatment Recommendations for Early-Stage Breast Cancer. J Natl Cancer Inst (2018) 110:493-500. PMID: 29237009. PMCID: PMC5946952.
Kurian, A. W.; Ward, K. C.; Hamilton, A. S.; Deapen, D. M.; Abrahamse, P.; Bondarenko, I.; Li, Y.; Hawley, S. T.; Morrow, M.; Jagsi, R.; Katz, S. J. Uptake, Results, and Outcomes of Germline Multiple-Gene Sequencing After Diagnosis of Breast Cancer. JAMA Oncol (2018) In process. PMID: 29801090.
Translational and Clinical Research
Li, J.; Johnson-Buck, A.; Yang, Y. R.; Shih, W. M.; Yan, H.; Walter, N. G. Exploring the speed limit of toehold exchange with a cartwheeling DNA acrobat. Nat Nanotechnol (2018) In process. PMID: 29736034.
Suddala, K. C.; Cabello-Villegas, J.; Michnicka, M.; Marshall, C.; Nikonowicz, E. P.; Walter, N. G. Hierarchical mechanism of amino acid sensing by the T-box riboswitch. Nat Commun (2018) 9:1896. PMID: 29760498. PMCID: PMC5951919.
INTER-PROGRAMMATIC PUBLICATIONS
Cancer Biology, Cancer Genetics, Developmental Therapeutics, & Translational and Clinical Research
Tan, Y. S.; Sansanaphongpricha, K.; Xie, Y.; Donnelly, C. R.; Luo, X.; Heath, B. R.; Zhao, X.; Bellile, E. L.; Hu, H.; Chen, H.; Polverini, P. J.; Chen, Q.; Young, S.; Carey, T. E.; Nor, J. E.; Ferris, R. L.; Wolf, G.; Sun, D.; Lei, Y. L. Mitigating SOX2-potentiated immune escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing nanosatellite vaccine. Clin Cancer Res (2018) In process. PMID: 29769207.
Cancer Genetics & Translational and Clinical Research
Mehra, R.; Vats, P.; Cao, X.; Su, F.; Lee, N. D.; Lonigro, R.; Premkumar, K.; Trpkov, K.; McKenney, J. K.; Dhanasekaran, S. M.; Chinnaiyan, A. M. Somatic Bi-allelic Loss of TSC Genes in Eosinophilic Solid and Cystic Renal Cell Carcinoma. Eur Urol (2018) In process. PMID: 29941307.
Cancer Genetics, Health Behavior and Outcomes, & Translational and Clinical Research
Zhang, Y.; Pitchiaya, S.; Cieslik, M.; Niknafs, Y. S.; Tien, J. C.; Hosono, Y.; Iyer, M. K.; Yazdani, S.; Subramaniam, S.; Shukla, S. K.; Jiang, X.; Wang, L.; Liu, T. Y.; Uhl, M.; Gawronski, A. R.; Qiao, Y.; Xiao, L.; Dhanasekaran, S. M.; Juckette, K. M.; Kunju, L. P.; Cao, X.; Patel, U.; Batish, M.; Shukla, G. C.; Paulsen, M. T.; Ljungman, M.; Jiang, H.; Mehra, R.; Backofen, R.; Sahinalp, C. S.; Freier, S. M.; Watt, A. T.; Guo, S.; Wei, J. T.; Feng, F. Y.; Malik, R.; Chinnaiyan, A. M. Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression. Nat Genet (2018) 50:814-824. PMID: 29808028. PMCID: PMC5980762.
Cancer Genetics, Cancer Hematopoiesis and Immunology, & Translational and Clinical Research
Wu, Y. M.; Cieslik, M.; Lonigro, R. J.; Vats, P.; Reimers, M. A.; Cao, X.; Ning, Y.; Wang, L.; Kunju, L. P.; de Sarkar, N.; Heath, E. I.; Chou, J.; Feng, F. Y.; Nelson, P. S.; de Bono, J. S.; Zou, W.; Montgomery, B.; Alva, A.; Robinson, D. R.; Chinnaiyan, A. M. Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. Cell (2018) 173:1770-1782.e14. PMID: 29906450.