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James A Knol MD



James A. Knol, M.D., is the Cyrenus G. Darling, Sr. and Cyrenus G. Darling Jr. Professor of Surgery and a member of the Division of Gastrointestinal Surgery in the Section of General Surgery. He is a member of the University of Michigan Rogel Cancer Center. Dr. Knol received his bachelors degree at Calvin College in Grand Rapids, Michigan, and received his M.D. degree from the University of Michigan Medical School in 1974. He completed a General Surgery residency at the University of Michigan in 1980. He has been on the Surgery faculty at the University of Michigan since 1980. He is Board Certified in General Surgery. Dr. Knol's clinical practice is gastrointestinal surgery which includes all aspects of surgical care for the stomach, small intestine, colon, rectum, anus, liver, gallbladder, bile ducts, and pancreas, including diagnostic endoscopy and laparoscopic surgery. He also performs surgery for portal hypertension. 

Clinical Specialization

Dr. Knol's clinical practice has an emphasis on gastrointestinal cancer, particularly, cancers involving the liver, bile ducts, and gallbladder, but also cancer of the colon, small intestine, stomach, and pancreas. Expertise includes liver resection for benign and malignant disease, cryosurgery and radiofrequency ablation for liver cancer, and access for regional hepatic arterial chemotherapy. 


Medical School or Training
  • University of Michigan Medical School, 1974
  • University of Michigan Health System, Surgery General, MI, 1980
Professional Organizations
  • Fellow, American College of Surgeons
Board Certification
  • Surgery


His research interests are in the treatment of primary and secondary liver cancers, using multidisciplinary regional approaches.