Rogel Cancer Center Researchers Present at AACR Annual Meeting

ED025 - Innovations in Methods for Adapting and Personalizing Interventions for Cancer Control

Inbal Nahum-Shani, Chair and Presenter
10:00 AM – 11:30 AM
Room W312 - Convention Center

Making phase I trials relevant: Aligning need with design

Thomas M. Braun
10:05 AM – 10:25 AM
Valencia D - Convention Center

Establishment and regulation of the pancreatic cancer microenvironment

Marina Pasca Di Magliano
12:30 PM – 12:50 PM
Tangerine Ballroom 2 (WF2) - Convention Center

MS.ET09.01 - Small Molecule Therapeutic Agents

Judy Leopold, Chair
3:00 PM – 5:00 PM
Room W224 - Convention Center

1160 - A machine learning based method for in-vivo metabolic flux analysis of patient tumors

Anjali Mittal
4:07 PM – 4:22 PM
Room W304 A-D - Convention Center

Poster Session, 1:30-5:00 PM

994 / 4 - Chiroptical detection and mutation analysis of cancer-associated extracellular vesicles in microfluidic devices with oriented chiral nanoparticles

Abha Kumari
Section 41

1068 / 12 - A precision CRISPR approach to target structural variant junctions in cancer

Radhika Suhas Hulbatte
Section 43

1092 / 5 - Targeting one-carbon metabolism radiosensitizes pancreatic ductal adenocarcinoma cells (PDAC)

Minal Nenwani
Section 44

1093 / 6 - Measuring and inhibiting purine metabolism in patients with glioblastoma

Daniel R. Wahl
Section 44

1095 / 8 - Exploiting altered methionine metabolism to overcome treatment resistance in glioblastoma

Navyateja Korimerla
Section 44

595 / 29 - Targeting metabolic vulnerability in brain-metastatic HER2+ breast cancer

Habib Serhan
Section 20

331 / 11 - Mitochondrial transfer from astrocytes drives glioblastoma tumorigenicity

Dionysios C. Watson
Section 12

AOS09 - Informing Future Precision Medicine Trials for Pancreatic Cancer

Marina Pasca di Magliano
10:45 AM – 11:05 AM
Valencia BC - Convention Center

SY13 - New Horizons for T Cell Immunity and Checkpoints

Weiping Zou
1:00 PM – 1:20 PM
Tangerine Ballroom 2 (WF2) - Convention Center

MS.CH01.01 - New Targeted Protein Degraders: Discovery and Novel Design Strategies

Yu Chang
3:37 PM – 3:52 PM
Room W224 - Convention Center

MS.MD01.02 - Molecular Pathway Discovery and Translation in Solid Tumors

3:21 PM – 3:36 PM
Weihua Zhou
Room W304 A-D - Convention Center

TM02 - Cancer Immunoprevention: A Cancer Immunology Working Group Town Hall Meeting and Networking Reception

Yu Leo Lei
6:50 PM – 7:00 PM
Windermere X - Hyatt Regency

Poster Session, 9:00 AM - 12:30 PM

2036 / 5 - Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Michael Mumphrey
Section 32

2026 / 10 - Comprehensive metabolic flux analysis on triple-negative breast cancer shows potential collaterally lethal targets related to the serine pathway

Jin Heon Jeon
Section 31

2131 / 5 - Immunoaffinity isolation of EpCAM expressing exosomes utilizing high throughput microfluidic chip with IEDDA chemistry (EpCAM-TCOOncoBean Chip)

Nna-Emeka Onukwugha
Section 39

2115 / 18 - Zero-waste molecular diagnostics from biopsy needle wash water

Jack Wadden
Section 38

2256 / 3 - Cancer stem cells and exosomal PD-L1 suppress anti-tumor B cells

Ying Xin
Section 43

2279 / 26 - Tumor treating fields induce immune modulation in non-small cell lung cancer

Suhe Wang
Section 43

2236 / 13 - The role of CPI-613 in cholangiocarcinoma treatment

Fulei Wuchu
Section 42

2244 / 21 - Association of chromosomal instability with poor prognosis in metastatic hormone sensitive and castrate-resistant prostate cancer

Ryan J. Rebernick
Section 42

1679 / 4 - Unraveling the function of TRAF2 and NCK interacting kinase (TNIK) in high-grade serous ovarian cancer

Noah Puleo
Section 19

1685 / 10 - Overcoming acquired resistance to PROTAC degraders

Tongchen He
Section 19

1745 / 10 - Targeting therapeutic resistance of esophageal adenocarcinoma through modulating the epithelial-to-mesenchymal transition via NFκB-mediated signaling

Yun Zhang
Section 21

1570 / 18 - Novel Myc-dependent compound DL78 selectively induces mitotic catastrophe and cell death in high grade serous ovarian cancer

Jessica Teitel
Section 15

1634 / 24 - Novel autophagy inhibitor ESK981 potentiates MEK inhibition cytotoxicity in pancreatic cancer

Caleb Cheng
Section 17

1501 / 28 - Epigenetic dedifferentiation as a therapeutic strategy in adrenal cancer

Dipika R. Mohan
Section 12

1322 / 12 - Comparison of brain extracellular matrices in a blood brain barrier organ on a chip model

Ehsanul Hoque Apu
Section 5

Poster Session, 1:30 PM - 5:00 PM

LB163 / 14 - A microfluidic platform for developing circulating tumor cells (CTCs) organoids for precision medicine in pancreatic cancer

Yu Zhang
Section 36

3297 / 5 - Deep reactive ion etched microneedle array for in-vivo melanoma cancer monitoring via cancer exosome isolation

Scott M. Smith
Section 41

3354 / 29 - Isolation and characterization of circulating tumor cells from ductal carcinoma in situ patients using label free technology

Neha Nagpal
Section 42

CT151 / 13 - A phase II study of optimized individualized adaptive radiation therapy for hepatocellular carcinoma

Daniel J. Herr
Section 47

2820 / 11 - Defining the role of purine metabolism in radiation resistance in H3K27M–mutant diffuse midline glioma

Erik R. Peterson
Section 19

2823 / 14 - Targeting monopolar spindle kinase I (TTK) as a radiosensitizing strategy in syngeneic murine models of triple negative breast cancer (TNBC) and its implications on the tumor immune microenvironment

Kassidy M. Jungles
Section 19

2401 / 1 - Molecular mechanisms of intrinsic radioresistance in breast cancer

Breanna N. McBean
Section 3

AOS01 - Advances in Brain Tumor Research and Treatment

Carl Koschmann
12:35 PM – 12:55 PM
Room W307 - Convention Center

AACR James S. Ewing-Thelma B. Dunn Award for Outstanding Achievement in Pathology in Cancer Research

Arul M. Chinnaiyan
5:15 PM

Poster Session 9:00 AM - 12:30 PM

4536 / 15 - Investigating the correlation between molecular diagnostics, targeted therapies and treatment outcomes in Rosai Dorfman disease: a single-institution experience

Samuel B. Reynolds
Section 44

3909 / 28 - THY1 regulates therapy resistance in glioblastoma recurrence

Sunita Shankar
Section 16

3677 / 8 - DNA damage signaling activates de novo GTP synthesis to promote chemoradiation resistance in glioblastoma

Andrew J. Scott
Section 7

3550 / 1 - The ENL YEATS domain links leukemic stem cell frequency and enhances YEATS inhibitor sensitivity in MLL-ENL leukemias

Hsiangyu Hu
Section 2

3523 / 3 - A systematic comparison of molecular features shared by H3K27-altered diffuse midline gliomas and posterior fossa A ependymomas

Matthew Pun
Section 1

Poster Session, 1:30 PM - 5:00 PM

LB252 / 4 - HPV integration events are heterogenous, clonally selected and associated with spatially distinct transcriptomic profiles in aggressive HPV positive oropharyngeal squamous cell carcinoma

Wenjin Gu
Section 35

5581 / 5 - Single-cell genomic analysis of patient-derived circulating tumor cells in pancreatic cancer

Harrison Ball
Section 41

5502 / 20 - Androgen blockade confers sensitivity to PIKfyve inhibition in prostate cancer

Yuanyuan Qiao
Section 38

4700 / 13 - Spatial analysis of the immune microenvironment and tumor cell transition in sarcomatoid renal cell carcinoma

Allison May
Section 7

5595 /19 - Serial monitoring of circulating tumor cells and circulating tumor DNA in metastatic lobular breast cancer identifies intra-tumor heterogeneity and precision and immuno-oncology biomarkers of therapeutic importance

Andi Cani
Section 41

5259 / 13 - Bazedoxifene plus conjugated estrogen improves metabolic health and reduces mammary gland epithelial proliferation in an ovary intact rat model of obesity and breast cancer risk

Erin Giles
Section 27

ADT09 - Technical Advances in Liquid Biopsy and Rare Event Detection

Sunitha Nagrath, Chair and Presenter
10:15 AM – 11:45 AM
Room W414 - Convention Center

Poster Session 9:00 AM - 12:30 PM

6141 / 3 - Mechanisms by which Mito-lonidamine inhibits EGFR mutant lung cancer

Katherine M. Weh
Section 16

6286 / 24 - Targeting Polycomb Repressive Complex 1 with small-molecule inhibitors as a potential therapeutic approach to combat leukemia

Miranda L. Simes
Section 20

6423 / 10 - Targeting an autophagy regulator augments antitumor immunity and immunotherapy

Yi Bao
Section 25

6037 / 10 - Identification of collateral lethal targets in cancers using integrated machine learning and flux analysis platform for personalized metabolic therapy

Abhinav Achreja
Section 11

6529 / 27 - Early life liver proteomic signature and minerals mitigation of liver injury

Muhammad N. Aslam
Section 28

6496 / 17 - Exposure phenotype risk scores (E-PRS) and prostate cancer aggressiveness in the Michigan Genomics Initiative (MGI)

Xinman Zhang
Section 27

5835 / 8 - Targeting discoidin domain receptor 1 (DDR1) reverses glioma immune suppression by remodeling collagen fiber architecture

Syed M. Faisal
Section 3