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Experts explain their approach to treating patients who are living longer with cancer that has spread to the spine
Every kind of cancer can spread to the spine, yet two physician-scientists who treat these patients describe a lack of guidance for effectively providing care and minimizing pain.
To resolve the confusion and address the continually changing landscape of spine oncology, a recent Michigan Medicine-led publication details a guide to explain the management of the spread of cancer to the spine.
Published in The Lancet Oncology, the work is the result of reviewing all of the existing studies and pulling in experts from across the world to provide insight. The goal, says senior author Nicholas Szerlip, M.D., a neurosurgeon at the University of Michigan, is to get all providers on the same page.
First author Daniel Spratt, M.D., who with Szerlip co-founded U-M’s multidisciplinary spine oncology clinic, says patients with cancer tumors that have spread to the spine are commonly managed separately and without the benefits of the team approach to care common for people with other forms of cancer. A patient with a spine metastasis might see a variety of sub-specialty doctors. Recommendations could range from pain management to more aggressive treatment, and referring doctors don’t always know what will come out of a referral to spine oncology experts, or when a referral is necessary.
“Spine oncology is such a multidisciplinary pathology,” says Szerlip, an associate professor. “We wanted to form a transparent understanding so everyone, from the oncologists and primary care providers to fellow neurosurgeons who aren’t specifically trained on this, could lean on one algorithm in language we can all understand.”
Spratt describes the algorithm, a report from the researchers’ new International Spine Oncology Consortium, as a step-by-step method designed to help comprehensively manage these patients as they grow in number and their life spans lengthen after diagnosis. He says the goal is to help providers treat the patient and not just the tumor, taking into account the patient’s performance status, life expectancy, burden of systemic disease and available treatment options.
“Most of the frameworks that have been available prior to this have focused on just surgery or just radiation,” Spratt says. “This algorithm integrates all of the specialties together, including PM&R, radiology and medical oncology, to provide a much more personalized treatment approach for patients with metastatic cancer to the spine.”
A different approach
Cancer can spread widely through the body, yet this algorithm -- or guideline -- specifically focuses on cancers/tumors that have spread to the spine. Researchers say a metastasis in the spine throws a wrench in typical treatment plans because of the sensitivity of the spinal cord. Quality of life can worsen much faster.
“A spine metastasis causes a lot of pain,” Szerlip says. “People can live with metastases in other areas of the body without much discomfort, but bone pain hurts a lot, and the ability to treat a tumor near the spinal cord is less. Surgeries on other bones are much easier than surgeries on the spine, and less morbid.”
Popular treatment paths address both the neurologic benefit and the oncologic benefit. That might mean a surgical decompression of the tumor, followed by radiation to attempt to control the cancer. Spratt is particularly excited about offering spine stereotactic body radiotherapy (SBRT), a form of high-dose radiation that requires just one to three treatments. Conventional radiation results in only about a 50 percent reduction in pain three months after treatment, and the cancer is eliminated for only a short time. Spratt says spine SBRT is a game changer, showing greater than 90 percent pain reduction and more effectively controlling tumor growth beyond one year post-treatment.
“With this technique, you’ve basically spared the spinal cord so you can give a much higher dose just millimeters away,” he says.