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Menthol cigarettes are difficult to quit. What would make it easier?

Menthol cigarettes are designed to make it easier to start smoking and harder to quit. In Michigan, 40% of callers to the state’s Tobacco Quitline are menthol users. Now, a new partnership between the University of Michigan Rogel Cancer Center and the Quitline will develop and test strategies to help menthol users kick the habit.

Liquid Biopsy

The Liquid Biopsy Developing Shared Resource provides state-of-the-art engineering solutions and platforms to analyze liquid biopsies, including cell-free nucleic acid, circulating tumor cells, immune cells, and extracellular vesicles.

Service Highlights:

  • Extraction of cell-free nuclei acids
  • Microfluidics-based cell enrichment and enumeration
  • Single cell sorting
  • Digital droplet PCR (ddPCR)
  • Next-generation sequencing (NGS) library preparation
  • Ion Torrent-based NGS with variant and copy number analysis

Epigenetics and Epigenomics

Service Highlights

  • Nuclei isolation from cells & tissues for bulk & single-cell assays
  • Bulk ChIP- Seq & ATAC-Seq on cells or tissues (flash frozen, OCT)
  • Single nucleotide resolution of DNA methylation via eRRBS or WGBS
  • DNA hydroxymethylation
  • Bisulfite conversion for Illumina MethylationEPIC array
  • Bioinformatics for study design and post-procedure analysis

The Epigenetics and Epigenomics Developing Shared Resource provides expertise & services . . .

Rolling Opportunities

 

The rolling funding opportunities page has moved. It's open to the University of Michigan community and requires logging in to your University of Michigan account (previously referred to as your Level 1 sign-in): https://sites.google.com/umich.edu/rogel-communication-hub/researchers/funding-opportunities/rolling-opportunities

Daniel Chang to lead Department of Radiation Oncology at Michigan Medicine

Daniel Chang, M.D., was named chair of the Department of Radiation Oncology at Michigan Medicine. The University of Michigan Board of Regents approved the appointment at its Sept. 22 meeting. Chang, who is currently the Sue and Bob McCollum Professor of Radiation Oncology at Stanford University, will begin at U-M on Oct. 1.

Mathematics enable scientists to understand organization within a cell’s nucleus

Rogel researchers have developed a new mathematical technique to begin to understand how a cell’s nucleus is organized. The technique, tested on several types of cells, revealed what the researchers termed self-sustaining transcription clusters, a subset of proteins that play a key role in maintaining cell identity. They hope this understanding will expose vulnerabilities that can be targeted to reprogram a cell to stop cancer or other diseases.

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